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Journal of Cancer Prevention


Journal of Korean Association of Cancer prevention 2003; 8(3): 181-187

Published online June 30, 2003

© Korean Society of Cancer Prevention

Chemopreventive Effects of Angelica gigas Nakai Leaf (AGL) Kimchi and AGL Added Baechu Kimchi

Sun-Mi Choi, Jeung-Ha Kil, Suk-Hee Moon1 and Kung-Young Park


Chemopreventive effects of Angelica gigas Nakai leaf (AGL), AGL kimchi and AGL added baechu kimchi were investigated. Kimchis were fermented at 15oC for 1 day and then ripened at 5oC to reach optimum pH of 4.3. The fermented kimchis were freeze-dried and extracted with methanol. AGL, AGL kimchi and 1% AGL added baechu kimchi exhibited higher inhibitory activities against the mutagenicities induced by aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100 than the baechu kimchi. Especially, AGL showed the highest inhibitory effect, and the AGL added baechu kimchi increased the antimutagenicities compared to baechu kimchi (p<0.05). To investigate anticlastogenic effect of AGL and the kimchies in mice, supravital staining of micronucleus assay using mouse peripheral reticulocytes was performed. AGL revealed the highest anticlastogenic effect in mice against mitomycin C. Also, AGL and the AGL added kimchi were effective in reducing lung metastasis of colon 26-M3.1 cells. AGL kimchi and AGL added baechu kimchi increased chemopreventive effects of the kimchi and these results indicated that AGL addition increased chemopreventive effect of the kimchi.

Keywords: Kimchi, Angelica gigas Nakai, Ames test, Micronucleus assay, Metastasis

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