J Cancer Prev 2024; 29(4): 148-156
Published online December 30, 2024
https://doi.org/10.15430/JCP.24.024
© Korean Society of Cancer Prevention
Yonghoon Choi1,2 , Nayoung Kim1,2,3
, Seon Hee Lim4
, Ji Hyun Park3
, Jeong Hwan Lee1
, Yeejin Kim1
, Hyemin Jo1
, Ho-Kyoung Lee1
, Jinju Choi1
, Yu Kyung Jun1
, Hyuk Yoon1
, Cheol Min Shin1
, Young Soo Park1
, Dong Ho Lee1,2,3
1Department of Internal Medicine, 2Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, 3Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 4Department of Internal Medicine, Seoul National University Healthcare System Gangnam Center, and Healthcare Research Institute, Seoul, Korea
Correspondence to :
Nayoung Kim, E-mail: nakim49@snu.ac.kr, https://orcid.org/0000-0002-9397-0406
This is an Open Access article distrBifidobacterium longum, Irritable bowel syndrome, Rats, Probioticsibuted under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Serological tests for Helicobacter pylori needs local validation as the diagnostic accuracy may vary depending on the prevalence of H. pylori. This study examined the diagnostic performance of two ELISA, GastroPanel® (GastroPanel ELISA; Biohit Oyj) and GENEDIA ® (GENEDIA® H. pylori ELISA, Green Cross Co.) in Korean population. One thousand seventy seven patients who visited for esophagogastroduodenoscopy between 2013 and 2023 were prospectively enrolled, and serum samples from the subjects were tested using both GastroPanel® and GENEDIA®. The two tests were compared for their diagnostic accuracy in detecting atrophic gastritis (AG), intestinal metaplasia (IM), gastric adenoma (GA), and gastric cancer (GC), and the positivity rates by age and sex were observed. There was substantial correlation (Pearson coefficient [r] = 0.512, P < 0.001) and agreement (Cohen’s Kappa coefficient [κ] = 0.723, P < 0.001) between the results obtained using GastroPanel® and GENEDIA®. The test results from the two kits did not match perfectly with a discrepancy observed in approximately 16% of cases, that 67 subjects were positive only on GENEDIA ® while 75 subjects were positive only on GastroPanel®. The area under receiver operating characteristic curve for AG, IM, GA, and GC using GastroPanel® were 0.666, 0.635, 0.540, and 0.575, while the results tested using GENEDIA® were 0.649, 0.604, 0.553, and 0.555, respectively, without significant difference between the two results. GastroPanel® and GENEDIA® showed similar performance in terms of diagnostic accuracy; but the test results did not match perfectly. A large-scale validation study in Koreans is needed.
Keywords: Helicobacter pylori, Serology, Enzyme-linked immunosorbent assay, Diagnosis
Nilesh Kumar Sharma, Sachin C. Sarode, Gopinath Sekar, Kaveri Sonawane, Dhanashree Bomle
J Cancer Prev 2024; 29(4): 105-112 https://doi.org/10.15430/JCP.24.015Setthachai Piwchan, Kittipoom Tossapornpong, Suppana Chuensakul, Ekawee Sripariwuth
J Cancer Prev 2023; 28(4): 194-200 https://doi.org/10.15430/JCP.2023.28.4.194Weon-Seon Hong
Journal of Korean Association of Cancer prevention 2003; 8(4): 223-235