Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells

Min Chang Oh; Pincha Devage Sameera Madushan Fernando; Mei Jing Piao; Kyoung Ah Kang; Herath Mudiyanselage Udari lakmini Herath; Jin Won Hyun

doi:10.15430/JCP.2023.28.2.40

Original Article

J Cancer Prev 2023; 28(2): 40-46

Published online June 30, 2023

https://doi.org/10.15430/JCP.2023.28.2.40

Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells

Min Chang Oh^1,*, Pincha Devage Sameera Madushan Fernando^1,*, Mei Jing Piao^1,2, Kyoung Ah Kang^1,2, Herath Mudiyanselage Udari lakmini Herath¹, Jin Won Hyun^1,2

¹Department of Biochemistry, Jeju National University College of Medicine, ²Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Korea

Correspondence to :
Jin Won Hyun, E-mail: jinwonh@jejunu.ac.kr, https://orcid.org/0000-0002-3403-3762
*These authors contributed equally to this work as co-first authors.

Received: May 22, 2023; Revised: June 13, 2023; Accepted: June 13, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.

Keywords: &alpha,-Melanocyte-stimulating hormone, Baicalein, Carcinogenesis, Monophenol monooxygenase, B16F10 cells

Original Article

Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells

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