닫기
Article Search
닫기

Journal of Cancer Prevention

Original Article

J Cancer Prev 2022; 27(4): 221-228

Published online December 30, 2022

https://doi.org/10.15430/JCP.2022.27.4.221

© Korean Society of Cancer Prevention

Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins

Soojung Jin1,* , Jung-ha Park1,2,3,* , Hee Jung Yun2,3 , You Na Oh1 , Seunghye Oh3 , Yung Hyun Choi1,4 , Byung Woo Kim2,3,5,** , Hyun Ju Kwon1,2,3,5,**

1Core-Facility Center for Tissue Regeneration, Dong-eui University, 2Biopharmaceutical Engineering Major, Division of Applied Bioengineering, College of Engineering, Dong-eui University, 3Department of Biopharmaceutics, Dong-eui University Graduate School, 4Department of Biochemistry, College of Korean Medicine, 5Blue-Bio Industry Regional Innovation Center, Dong-eui University, Busan, Korea

Correspondence to :
Hyun Ju Kwon, E-mail: hjkwon@deu.ac.kr, https://orcid.org/0000-0002-1375-0906
Byung Woo Kim, E-mail: bwkim@deu.ac.kr, https://orcid.org/0000-0001-7940-1074
*These authors contributed equally to this work as co-first authors.
**These authors contributed equally to this work as co-correspondence authors.

Received: November 28, 2022; Revised: December 18, 2022; Accepted: December 27, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Erratum: J Cancer Prev 2023; 28(2): 75-75

Abstract

Go to

Cedrol, a sesquiterpene alcohol, isolated from Juniperus chinensis has been reported to inhibit minichromosome maintenance (MCM) proteins as cancer biomarkers in human lung cancer in vitro. In the present study, we investigated the anti-cancer activity of cedrol in vitro and in vivo using human colorectal cancer HT29 cells and a human colorectal tumor xenograft model. Cedrol inhibited MCM protein expression and cell growth in HT29 cells, which are associated with G1 arrest and the induction of apoptosis. We demonstrated that cedrol effectively reduced HT29 tumor growth without apparent weight loss in a human tumor xenograft model. Compared with vehicle- and adriamycin-treated tumor tissues, cedrol induced changes in the tumor tissue structure, resulting in a reduced cell density within the tumor parenchyma and reduced vascularization. Moreover, the expression of MCM7, an important subunit of MCM helicase, was significantly suppressed by cedrol in tumor tissue. Collectively, these results suggest that cedrol may act as a potential anti-cancer agent for colorectal cancer by inhibiting MCM protein expression and tumor growth.

Keywords: Apoptosis, Cedrol, Colorectal cancer, G1 arrest, Minichromosome maintenance proteins

Article Tools

Metrics

Share this article on :

Related articles in JCP

Most KeyWord