J Cancer Prev 2022; 27(3): 182-191
Published online September 30, 2022
© Korean Society of Cancer Prevention
Larissa Akemi Kido1,2 , Isabela Maria Urra Rossetto1 , Andressa Mara Baseggio2 , Gabriela Bortolanza Chiarotto1 , Letícia Ferreira Alves1 , Felipe Rabelo Santos1 , Celina de Almeida Lamas1 , Mário Roberto Maróstica Jr2 , Valéria Helena Alves Cagnon1
1Department of Structural and Functional Biology, Institute of Biology, 2Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, São Paulo, Brazil
Correspondence to :
Larissa Akemi Kido, E-mail: firstname.lastname@example.org, https://orcid.org/0000-0002-3653-8035
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Jaboticaba is a Brazilian berry, which is rich in fibers and bioactive compounds and shows high antioxidant and antiproliferative activities. Prostate cancer (PCa) is the second most common type of cancer among men and its progression is influenced by androgens and inflammation. Previous studies reported the ability of the jaboticaba to modulate pathways involved in prostate diseases. The main objective of this study was to provide significant data about molecular targets of the jaboticaba peel extract (JPE) and its mechanisms of action in PCa cell lines with different androgenic status (LNCaP and PC-3). The results showed that JPE was able to decrease cell viability in both cell lines. LNCaP showed more sensitivity to JPE exposure, indicating the efficacy of the JPE treatment in terms of androgen responsiveness. JPE showed a distinct hormone dependent effect on the NF-κB signaling, with reduced NF-κB levels for LNCaP and increased NF-κB levels in PC-3 cells. Mechanisms related to cell death by apoptosis were stimulated after the JPE treatment, modulating B-cell lymphoma 2 and BAX for LNCaP and PC-3. Particularly for PC-3, the JPE treatment resulted in cytokine-cytokine receptor interaction activation mostly by up regulating pro-inflammatory, pro-angiogenic, immunostimulatory and immunosuppressive genes. Also, a set of genes related to angiogenesis and metastasis were down-regulated by JPE. In conclusion, JPE exerted an antitumor effect on PCa for both cell lines which can be enhanced if androgenic reliance is considered.
Keywords: Biological products, Jaboticaba, Polyphenols, Prostate cancer, Inflammation
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