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Journal of Cancer Prevention

Review

J Cancer Prev 2022; 27(3): 157-169

Published online September 30, 2022

https://doi.org/10.15430/JCP.2022.27.3.157

© Korean Society of Cancer Prevention

Role of Post-translational Modification of Silent Mating Type Information Regulator 2 Homolog 1 in Cancer and Other Disorders

Yeon-Hwa Lee1 , Su-Jung Kim2 , Young-Joon Surh1,3

1Research Institute of Pharmaceutical Sciences, College of Pharmacy, 2Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, 3Cancer Research Institute, Seoul National University, Seoul, Korea

Correspondence to :
Young-Joon Surh, E-mail: surh@snu.ac.kr, https://orcid.org/0000-0001-8310-1795

Received: September 1, 2022; Revised: September 14, 2022; Accepted: September 16, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Silent mating type information regulator 2 homolog 1 (SIRT1), an NAD+-dependent histone/protein deacetylase, has multifarious physiological roles in development, metabolic regulation, and stress response. Thus, its abnormal expression or malfunction is implicated in pathogenesis of various diseases. SIRT1 undergoes post-translational modifications, including phosphorylation, oxidation/reduction, carbonylation, nitrosylation, glycosylation, ubiquitination/deubiquitination, SUMOylation etc. which can modulate its catalytic activity, stability, subcellular localization, and also binding affinity for substrate proteins. This short review highlights the regulation of SIRT1 post-translational modifications and their pathophysiologic implications.

Keywords: Post-translational modification, Protein processing, Sirtuin 1

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