J Cancer Prev 2022; 27(1): 42-49
Published online March 30, 2022
© Korean Society of Cancer Prevention
Jong Su Kang1,** , Xin Yi Zhao2,** , Jeong Ho Lee3 , Jeong-Sang Lee2,* , Young-Sam Keum1,*
1College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Goyang, 2Department of Biotechnology and Functional Foods, College of Medical Sciences, Jeonju University, Jeonju, 3Sunchang Research Institute of Health and Longevity, Sunchang, Korea
Correspondence to :
Jeong-Sang Lee, E-mail: email@example.com, https://orcid.org/0000-0002-2080-2065
Young-Sam Keum, E-mail: firstname.lastname@example.org, https://orcid.org/0000-0002-9348-466X
*These authors contributed equally to this work as co-correspondence authors.
**These authors contributed equally to this work as co-first auhtors.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the ethanol extract of Chaenomeles sinensis scavenged 2,2’-diphenylpicrylhydrazyl and 2,2’-azinobis diammonium radicals in vitro. The ethanol extract of Chaenomeles sinensis activated antioxidant response element-luciferase activity and induced expression of NRF2 target genes in HaCaT cells. The ethanol extract of Chaenomeles sinensis also suppressed LPS-induced expression of COX-2 and iNOS proteins, and mRNA expression of TNF-α and IL-2 in RAW264.7 cells. Finally, the ethanol extract of Chaenomeles sinensis significantly suppressed testosterone propionate-induced benign prostatic hyperplasia in mice. Together, our study provides the evidence that the ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects.
Keywords: Benign prostatic hyperplasia, Chaenomeles sinensis, NF-E2-related factor 2, Lipopolysaccride, Oxidative stress
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