J Cancer Prev 2022; 27(1): 31-41
Published online March 30, 2022
https://doi.org/10.15430/JCP.2022.27.1.31
© Korean Society of Cancer Prevention
Qinglong Liu1,2 , Xiaojing Li1,2
, Hao Zhang1,2,3
, Haitao Li1,2
1State Key Laboratory of Food Science and Technology, Jiangnan University, 2School of Food Science and Technology, Jiangnan University, 3National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China
Correspondence to :
Haitao Li, E-mail: liht@jiangnan.edu.cn, https://orcid.org/0000-0002-1493-8679
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mannose has recently drawn extensive attention for its substantial anti-cancer activities, but the underlying mechanism remains largely unclear. The aim of this study was to investigate the effects of mannose on experimental colitis-associated colorectal tumorigenesis and underlying mechanisms. Data clearly showed that at plasma concentrations achieved after oral administration, mannose slightly affected malignancy of tumor cells or tumor promoter-induced transformation of pre-neoplastic cells, but substantially suppressed manifestation of the M2-like phenotype of tumor-associated macrophages (TAMs) in a cancer cell and macrophage co-culture model. Mechanistically, mannose might greatly impair the production of tumor cell-derived lactate which has a critical role in the functional polarization of TAMs. Importantly, oral administration of mannose protected mice against colitis-associated colorectal tumorigenesis by normalizing TAM polarization. Collectively, these findings highlight the importance of TAMs in colorectal tumorigenesis, and provide a rationale for introducing mannose supplementation to patients suffering from inflammatory bowel diseases.
Keywords: Colorectal cancer, Mannose, Tumor-associated macrophages, Lactate
Darshika Amarakoon, Wu-Joo Lee, Jing Peng, Seong-Ho Lee
J Cancer Prev 2024; 29(4): 175-184 https://doi.org/10.15430/JCP.24.014Eun-Hye Jeon, So-Young Park, Keon Uk Park, Yun-Han Lee
J Cancer Prev 2024; 29(2): 25-31 https://doi.org/10.15430/JCP.24.004Soojung Jin, Jung-ha Park, Hee Jung Yun, You Na Oh, Seunghye Oh, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon
J Cancer Prev 2022; 27(4): 221-228 https://doi.org/10.15430/JCP.2022.27.4.221