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Journal of Cancer Prevention

Original Article

J Cancer Prev 2021; 26(4): 250-257

Published online December 30, 2021

© Korean Society of Cancer Prevention

Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

Hongwei Li1,* , Xingzhuang Zhu1,2,* , Wei Zhang1,* , Wenjie Lu1,2 , Chuan Liu3 , Jinbo Ma1 , Rukun Zang1 , Yipeng Song1,2

1Department of Radiation Oncology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 2Department of Oncology, School of Medicine, Qingdao University, Qingdao, 3Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Correspondence to :
Yipeng Song, E-mail:,
Rukun Zang, E-mail:,
*These authors are co-first authors and contributed equally to this work.

Received: August 12, 2021; Revised: September 20, 2021; Accepted: September 23, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (ESCC). In this study, we compared the expression of MTFR2 in 6 ESCC tumors and relative normal tissues by immunohistochemistry (IHC). To assess the effect of MTFR2 expression on clinicopathologic characteristics and survival, 115 paraffin embedded ESCC tissue samples were assessed by IHC staining. Furthermore, the association between clinicopathological properties and MTFR2 expression in patients with ESCC was examined. The survival analysis was performed using the Cox regression models. We found that MTFR2 expression was significantly increased in ESCC tumors compared with normal esophageal epithelial cells. IHC analysis of 115 paraffin embedded ESCC tumor specimens of the patients showed that the expression of MTFR2 was significantly associated with clinical stage (P < 0.001), tumor classification (P < 0.001), histological grade (P < 0.001), and other clinicopathological characteristics. Both univariate and multivariate analyses showed that MTFR2 expression was inversely correlated with the survival of ESCC patients. In conclusion, the expression of MTFR2 is significantly associated with clinicopathologic characteristics and prognosis of ESCC. Thus, MTFR2 expression could serve as a potentially important prognostic biomarker and clinical target for patients with ESCC.

Keywords: MTFR2, Esophageal squamous cell carcinoma, Immunohistochemistry, Prognosis

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