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Journal of Cancer Prevention

Review

Journal of Cancer Prevention 2019; 24(2): 65-71

Published online June 30, 2019

https://doi.org/10.15430/JCP.2019.24.2.65

© Korean Society of Cancer Prevention

The Role of Peroxiredoxin Family in Cancer Signaling

Yosup Kim1, Ho Hee Jang1,2

1Department of Health Sciences and Technology, Graduate School of Medicine, Gachon University, 2Department of Biochemistry, College of Medicine, Gachon University, Incheon, Korea

Correspondence to :
Ho Hee Jang
E-mail: hhjang@gachon.ac.kr, ORCID: Ho Hee Jang, https://orcid.org/0000-0003-0314-8230

Received: June 18, 2019; Revised: June 22, 2019; Accepted: June 24, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed in diverse intracellular locations. They are involved in the regulation of various physiological processes including cell growth, differentiation, apoptosis, immune response and metabolism as well as intracellular ROS homeostasis. Although there are increasing evidences that Prxs are involved in carcinogenesis of many cancers, their role in cancer is controversial. The ROS levels in cancer cells are increased compared to normal cells, thus promoting cancer development. Nevertheless, for various cancer types, an overexpression of Prxs has been found to be associated with poor patient prognosis, and an increasing number of studies have reported that tumorigenesis is either facilitated or inhibited by regulation of cancer-associated signaling pathways. This review summarizes Prx isoforms and their basic functions, the relationship between the expression level and the physiological role of Prxs in cancer cells, and their roles in regulating cancer-associated signaling pathways.

Keywords: Peroxiredoxins, Oxidative stress, Cancer, Peroxidase activity, Tumorigenesis

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