Journal of Cancer Prevention 2018; 23(1): 18-24
Published online March 30, 2018
https://doi.org/10.15430/JCP.2018.23.1.18
© Korean Society of Cancer Prevention
Joon-yeop Yang1, Xiancai Zhong1, Su-Jung Kim1, Do-Hee Kim1, Hyun Soo Kim1, Jeong-Sang Lee2, Hye-Won Yum1, Jeewoo Lee1, Hye-Kyung Na3, and Young-Joon Surh1
1Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, Korea, 2Department of Functional Food and Biotechnology, College of Medical Science, Jeonju University, Jeonju, Korea, 3Department of Food Science and Biotechnology, College of Knowledge-based Services Engineering, Sungshin Women’s University, Seoul, Korea
Correspondence to :
Young-Joon Surh, Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea, Tel: +82-2-880-7845, Fax: +82-2-883-2906, E-mail: surh@snu.ac.kr, ORCID: Young-Joon Surh,
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Curcumin, a yellow ingredient of turmeric ( Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0.1 or 0.25 mmol/kg body weight daily) for 7 days before and together with DSS administration (3% in tap water). Collected colon tissue was used for histologic and biochemical analyses. Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-κB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. In contrast to curcumin, its non-electrophilic analogue, tetrahydrocurcumin has much weaker inhibitory effects. Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-κB and STAT3.Background
Methods
Results
Conclusions
Keywords: Curcumin, Dextran sulfate sodium-induced colitis, NF-κB, STAT3, Tetrahydrocurcumin
Kyunghwa Cho, Hee Geum Lee, Juan-Yu Piao, Su-Jung Kim, Hye-Kyung Na, Young-Joon Surh
J Cancer Prev 2021; 26(2): 118-127 https://doi.org/10.15430/JCP.2021.26.2.118Joon-Yeop Yang, Xiancai Zhong, Hye-Won Yum, Hyung-Jun Lee, Joydeb Kumar Kundu, Hye-Kyung Na, and Young-Joon Surh
Journal of Cancer Prevention 2013; 18(2): 186-191 https://doi.org/10.15430/JCP.2013.18.2.186Su-Jung Kim, Nam-Chul Cho, Young-Il Hahn, Seong Hoon Kim, Xizhu Fang, Young-Joon Surh
J Cancer Prev 2021; 26(3): 207-217 https://doi.org/10.15430/JCP.2021.26.3.207