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Journal of Cancer Prevention

Original Article

Journal of Cancer Prevention 2016; 21(2): 104-109

Published online June 30, 2016

https://doi.org/10.15430/JCP.2016.21.2.104

© Korean Society of Cancer Prevention

Human Papillomavirus Prevalence and Type Distribution Among 968 Women in South Korea

Kyeong A So1, Jin Hwa Hong2, and Jae Kwan Lee2

1Department of Obstetrics and Gynecology, Cheil General Hospital & Women’s Healthcare Center, Dankook University Medical College, Seoul, Korea, 2Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea

Correspondence to :
Jae Kwan Lee, Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea, Tel: +82-2-2626-3142, Fax: +82-2-838-1560, E-mail: jklee38@korea.ac.kr, ORCID: Jae Kwan Lee, http://orcid.org/0000-0003-3101-6403

Received: March 5, 2016; Revised: April 19, 2016; Accepted: April 22, 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Background:

Geographic variation in the prevalence of carcinogenic types and human papillomavirus (HPV) genotype distribution is closely associated with the impact of HPV prophylactic vaccines. We determined the prevalence and distribution of HPV genotypes among healthy women in Korea.

Methods:

This study included 968 healthy women who were examined at a health promotion center of the Korea University Guro Hospital between January and June 2013. Each participant had a Pap test and a HPV DNA test using the Anyplex™ II HPV 28 Detection system, which detects 19 high-risk HPVs (HR HPVs) and 9 low-risk HPVs (LR HPVs). Women with abnormal cytology and/or positivity for HR HPVs were referred to colposcopic biopsy.

Results:

Overall HR HPV prevalence based on the assay was 33.7%. Among them, 225 women had single infection and 101 women had multiple infection. The most frequently occurring HR HPV types were 53 (6.5%), 52 (6.1%), 58 (4.8%), 16 (4.5%), and 68 (4.2%). The most frequently occurring LR HPV types were 54 (5.4%), 70 (3.8%), 42 (3.6%), 61 (3.4%), and 44 (3.1%). The prevalence of HPV 16 was highest (17.6%) among women with cervical intraepithelial neoplasia (CIN) and HPV 16 was strongly associated with a diagnosis of CIN2/3 (odds ratio = 20.5; 95% confidence interval: 3.9–107.1; P < 0.0001).

Conclusions:

HPV 53, 52, 58, 16, and 68 were common HR HPV types among healthy Korean women. HPV16 was the most common type in high-grade CIN lesions, as shown in most studies worldwide. The results might be useful information for cervical cancer prevention in South Korea.

Keywords: Human papillomavirus, Cervical intraepithelial neoplasia, Cytology

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