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Journal of Cancer Prevention

Original Article

Journal of Cancer Prevention 2013; 18(2): 161-168

Published online June 30, 2013

https://doi.org/10.15430/JCP.2013.18.2.161

© Korean Society of Cancer Prevention

The Anti-inflammatory Effects of Acidic Polysaccharide from Artemisia capillaris on Helicobacter pylori Infection

Jong-Min Park1, Ki-Baik Hahm1,2, Sang-Oh Kwon3, and Eun-Hee Kim1,4

1CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul, 2Department of Gastroenterology, CHA Bundang Medical Center, Seongnam, 3S&D Co., Ltd., Osong, 4College of Pharmacy, CHA University, Pocheon, Korea

Correspondence to :
Eun-Hee Kim, CHA Cancer Prevention Research Center and College of Pharmacy, CHA University, 605 Yeoksam 1-dong, Gangnam-gu, Seoul 135-081, Korea Tel: +82-2-3468-2869, Fax: +82-2-3468-2868, E-mail: ehkim@cha.ac.kr

Received: June 16, 2013; Revised: June 19, 2013; Accepted: June 19, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Background: 

Helicobacter pylori infection is associated with diverse upper gastrointestinal diseases, such as peptic and duodenal ulcers as well as gastric cancer. Longstanding period of infection impose great risk of H. pylori-related gastric disease, based on the evidence that early childhood infection is responsible for ensuing atrophic gastritis and gastric cancer related to H. pylori infection. Artemisiahas been known to be beneficial for heath for a long time. In spite of well-acknowledged cytoprotective and anti-inflammatory actions of Artemisia, the effects of the acidic polysaccharide fractions on the gastroprotection remain to be investigated. 

Methods: 
In the current study, we compared anti-inflammatory actions of the acidic polysaccharide fraction between Artemisia and Panax ginseng against H. pylori infection in vitro. The polysaccharide fractions were pretreated 1 h before H. pylori infection on normal gastric mucosal RGM-1 cells and gastric cancer MKN-28 cells. RT-PCR and Western blot was performed to check anti-inflammatory actions. 

Results: 
The expressions of inflammatory markers including COX-2, iNOS and IL-8 increased after H. pylori infection, of which levels were significantly decreased when treating with the polysaccharide fractions from Artemisia and ginseng in RGM1 and gastric cancer MKN-28 cells. In addition, the polysaccharide fractions significantly ameliorated H. pylori-induced angiogenic and invasive markers such as HIF-1α and ICAM1. Moreover, H. pylori-induced apoptosis were prevented by pretreatment with the polysaccharide fractions. The polysaccharide fraction from Artemisia showed the most protective effects among the several polysaccharide fractions used in this study.

Conclusions: 
The polysaccharide fraction of Artemisia capillariscan is a candidate substance which can attenuate either H. pylori-induced gastritis or tumorigenesis based on potent anti-inflammatory action.

Keywords: Helicobacter pylori, Anti-inflammation, Artemisia capillaries, Polysaccharide, RGM-1

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