The purpose of this study was to investigate the serum lipid profile and anti-inflammatory effects of Hizikia fusiforme according to the various extracts in Sprague-Dawley rat. Experimental group was divided into 6 groups: a control group (C), H. fusiforme ethanol extract group (EtOH), H. fusiforme dichloromethane fraction group (CH₂Cl₂), H. fusiforme ethylacetate fraction group (EtOAc), H. fusiforme butanol fraction group (n-BuOH), H. fusiforme water fraction group (H₂O), respectively. H. fusiforme extracts (400 mg/kg B.W) were orally administrated into rat every day for 4 weeks. The triglyceride concentrations were significantly decreased in CH₂Cl₂, n-BuOH and H₂O group compared to the control group (p＜0.05). The HDL-cholesterol levels of the EtOH and H₂O group were significantly higher than the control group (p＜0.05). In the muscle tissue, the expression of iNOS was decreased in CH₂Cl₂ (39%) and EtOAc (28%) group compare to control group. The expression of COX-2 in the liver was inhibited in the CH₂Cl₂ (60%) and n-BuOH (48%) group compared to control group. In the muscle tissue, the expression of COX-2 were inhibited in the n-BuOH and H₂O group (33% and 58%) compared to control group. It was found from the results suggest that H. fusiforme extract could be effective on serum lipid profile and expression of anti-inflammatory mediators. (Cancer Prev Res 17, 17-175, 2012)

Keywords: Hizikia fusiforme, lipid profile, iNOS, COX-2