Cancer prevention research 2011; 16(3): 263-268
Published online September 30, 2011
© Korean Society of Cancer Prevention
Ji Eun Jung and Eun Ju Cho
The anti-inflammatory effect of Zizyphus jujuba (Zj) and fermented Zj was investigated under cellular system using RAW 264.7 macrophages. The treatment of exotoxin and endotoxin, sodium nitroprusside (SNP) and lipopolysaccharie (LPS)+interferon-Ճ (IFN-Ճ), to RAW 264.7 macrophages induced cellular damage by the production of nitric oxide (NO). However, Zj and fermented Zj alleviated oxidative stress induced by SNP and LPS+IFN-Ճ, resulting in inhibition of NO production. Furthermore, Zj and fermented Zj down-regulated the inflammation-related mRNA expressions, cyclooxygenase-2 and inducible NO synthase, under LPS+IFN-Ճ-stimulated RAW 264.7 macrophages. In addition, the anti-inflammatory effect of fermented Zj, in particular Zj fermented by Saccaromyces cerevisiae, was stronger than that of non-fermented Zj. The present study indicated that Zj exerted the protective role from NO-induced inflammation and fermentation process enhanced the anti-inflammatory activity. (Cancer Prev Res 16, 263-268, 2011)
Keywords: Zizyphus jujuba, Fermentation, Nitric oxide, Inflammation, RAW 264.7 macrophages
Earl Han, Eunyoung Ha, Sung-Hoon Kim, Joo-Ho Chung, Hyung Hwan Baik and Ju Yeon Ban
Cancer prevention research 2010; 15(2): 138-142Hwana Han, Joo Weon Lim, Hyeyoung Kim
J Cancer Prev 2020; 25(4): 244-251 https://doi.org/10.15430/JCP.2020.25.4.244Ha-Neul Choi, Jung-Eun Yim
J Cancer Prev 2018; 23(4): 191-196 https://doi.org/10.15430/JCP.2018.23.4.191