In this study, we examined the effects of Sea Tangle (Laminaria japonica) supplementation and regular exercise on the expression of anti-inflammatory mediators in liver of stress-stimulated rat. Stress significantly induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in the liver, however Sea Tangle supplementation and regular exercise significantly inhibited stress-induced the levels of iNOS and COX-2 proteins. To investigate the mechanism by which Sea Tangle supplementation and regular exercise inhibited iNOS and COX-2 expression, we examined the extent of IkappaB (IՊB) degradation. Sea Tangle supplementation and regular exercise significantly attenuated the stress-induced IՊB degradation. Taken together, these findings provide important new insights that Sea Tangle supplementation and regular exercis exhibits anti-inflammatory properties by suppressing the transcription of pro-inflammatory cytokine genes through the nuclear factor-kappaB (NF-ՊB) signaling pathway. (Cancer Prev Res 15, 211-216, 2010)

Keywords: Sea tangle, Exercise, iNOS, COX-2, IՊ,B