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Journal of Cancer Prevention

Original Article

Cancer prevention research 2010; 15(2): 118-126

Published online June 30, 2010

© Korean Society of Cancer Prevention

5-Aza-2'-deoxycytidine Induces Cell Cycle Arrest and the Cytoskeletal Reorganization by Recovery of Chimaerin2 in 267B1/K-ras Human Prostate Cancer Cells

Ji Young Lim1, Sook Jung Jeong2, Bo Yeon Kim2 and Gun-Do Kim1


5­Aza­2'­deoxycytidine, a demethylating agent, induced recovery of the expression of tumor suppressor genes. Chimaerin2 among these genes down-regulated the expression of Rac, WAVE2, Arp2/3, and Villin1 in Rac­dependent cytoskeletal pathway and led to the changes of cell morphology, actin dynamics and cell migration in 267B1/K­ras. 5-Aza-2'-deoxycytidine, also, caused cell cycle arrest at G1 to S phase by the inhibition of the expression of Cyclin-dependent kinases (CDKs), and Cdc25A. The results represent that 5-Aza-2'-deoxycytidine causes cell cycle arrest and regulates Rac-dependent actin polymerization on 267B1/K-ras human prostate cancer cells. (Cancer Prev Res 15, 118-126, 2010)

Keywords: 5-Aza-2'-deoxycytidine, Chimaerin2, Villin1, Cell cycle arrest, Rac

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