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Journal of Cancer Prevention

Review Article

Cancer prevention research 2010; 15(2): 101-105

Published online June 30, 2010

© Korean Society of Cancer Prevention

Are Cyclophilins Foes or Friends?

Kiyoon Kim*, Kwon Jeong* and Wonchae Choe


Cyclophilins (Cyps) are intracellular proteins originally discovered as cellular binding proteins for immunosuppressive drug, CsA. Recently, many studies report important roles of Cyps in cancer cell biology. Cyclophilin A (CypA) is overexpressed in several types of cancer cell. It has been reported that CypA plays a role in cancer cell proliferation, or anti-apoptosis. Overexpressed CypA protects prostate cancer cells from hypoxia- or cisplatin-induced apoptosis. Also CypA has been known to regulate ERK1/2, Jak2, and Bcl2 signaling. Cyclophilin B (CypB) seems to have much more influence on breast cancer. It has been known that CypB can promote cancer cell proliferation, and its motility. More importantly, CypB antigenic epitopes have been used against lung cancer in clinical trail phase I. CypD and Cyp40 also have been studied in several cancer cells. CypD reduces mitochondria mediated apoptosis and Cyp40 positively modulates androgen-dependent prostate cancer cell growth. This review will mainly discuss biological functions of CypA and CypB in oxidative stress and human cancers. Also, we will briefly discuss the recent findings on the importance of other Cyps in human cancers. This study will eventually lead us to find valuable strategies for cancer treatment and prevention. (Cancer Prev Res 15, 101-105, 2010)

Keywords: Oxidative stress, Cancer, Cyclophilns

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