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Journal of Cancer Prevention

Original

Cancer prevention research 2006; 11(4): 305-310

Published online December 30, 2006

© Korean Society of Cancer Prevention

A Study on the Gene Expression Patterns of Bisphenol
A-exposed Nematode (Caenorhabditis elegans)

Chulwoo Lee1, Jeong Won Hwang2, Hwa Jin Jung2, Eun-Kyoung Kim1, Hyun-Mi Kim1,
Young-Hee Chung1, Kyunghee Choi1 and Young Rok Seo2

Received: August 25, 2006; Accepted: October 26, 2006

Abstract

Endocrine disruptors are potentially linked to decreases in fertility as well as increases in some types
of cancers throughout the animals including humans. Recently, soil-dwelling nematode Caenorhabditis
elegans (C. elegans) has been used to monitor the toxicity of endocrine disruptors. In this study, changes
in gene expression in C. elegans in response to endocrine disruptor bisphenol A were investigated with
a microarray consisting of the nematode-specific cDNA probes. Upon exposure to bisphenol A for 24
hrs, we found 26 different genes that were up- or down-regulated with statistically significant changes.
Cytochrome P450 and phosphatse genes were up-regulated, however, heat shock protein, collagen and
annexin were down-regulated. Compared to classical tests this C. elegans chip microarray will be useful
in generating gene expression profiles at the same time and be used for well regulated biomarker genes
to study of toxicogenomics more in detail.

Keywords: Nematode, Caenorhabditis elegans, Microarray, Bisphenol A

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