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Journal of Cancer Prevention

Original

Cancer prevention research 2006; 11(2): 144-148

Published online June 30, 2006

© Korean Society of Cancer Prevention

Antimutagenic and In Vitro Anticancer Effects of Grain Extracts

Su-Ok Kim, Sook-Hee Rhee, Kyung-Mi Hwang and Kun-Young Park

Abstract

Antimutagenic and in vitro anticancer effects of grain extracts were studied by Ames test on Salmonella typhimurium TA100 and MTT assay on AGS human gastric adenocarcinoma cells, respectively. The tested grains included brown rice, barley, Job's tear, glutinous millet, prosomillet and sorghum, which were divided into raw and heat processed grains. Raw grains were dried and grinded after washing, and the processed grains were steamed for 30 min by autoclaving (1.0∼1.5 kg/cm2) and were hot-air dried. All grains showed antimutagenic activities against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100, especially prosomillet and sorghum exhibited higher activities in both raw and the processed samples. In the MTT assay on the cancer cells, prosomillet showed again the highest in vitro anticancer activity, followed by sorghum and brown rice. The raw and the processed grains revealed no significantly different effects but the raw brown rice and sorghum samples (2.5 mg/ml) exhibited higher activities than the processed ones (p<0.05). However, the anticlastogenic effects of the raw and the processed brown rice did not show significantly different in micronuclei test on male ICR mice. And the methanol extracts of the both samples significantly reduced the micronuclei formations in the reticulocytes of the mice. From these result, the employed grains, especially prosomillet, sorghum, brown rice could possibly be good chemopreventive foods. (Cancer Prev Res 11, 144-149, 2006)

Keywords: Grains, Prosomillet, Sorghum, Brown rice, Antimutagenic, Anticancer

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