The anticancer effects of methanol extracts from garlic dried differently and the dried garlic added kochujang (Korean red pepper soybean paste) were evaluated on AGS human gastric and HT-29 human colon adenocarcinoma cells by MTT assay. Freeze dried garlic was made from a whole bulb garlic and hot-air dried garlic were prepared from a whole bulb, sliced and chopped garlic at 70^oC. Methanol extracts of the freeze dried garlic showed higher anticancer effects than those of hot-air dried garlic on AGS human gastric and HT-29 human colon adenocarcinoma cells. Among the hot-air dried garlic, sliced garlic showed the highest inhibition rate. The kochujang prepared with the freeze dried garlic showed higher anticancer effects than the kochujang with hot-air dried garlic on AGS human gastric and HT-29 human colon adenocarcinoma cells. Addition of the freeze dried garlic during kochujang preparation inhibited the growth of the cells in a concentration dependent manner. Addition of the dried garlics during kochujang preparation increased anticancer activities, especially freeze dried one was more effective. (Cancer Prev Res 10, 128-133, 2005)

Keywords: Kochujang, Garlic, Anticancer, MTT assay