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Journal of Cancer Prevention


Journal of Korean Association of Cancer prevention 2004; 9(2): 98-103

Published online June 30, 2004

© Korean Society of Cancer Prevention

In Vitro Anticancer Effect of Active Compounds from Chinese Cabbage Kimchi

Eun Ju Cho, Jae Sue Choi1, So Hee Kim2, Kun Young Park and Sook Hee Rhee


The isolation and further fractionation for active compounds with anticancer activity from dichloromethane fraction of Chinese cabbage kimchi were carried out, and β- sitosterol and ergost-5-en-3.beta-ol (linoleic acid derivative) were identified as major compounds from GC-MS, EI-MS spectrum, 1H-NMR and 13C-NMR spectrum. The active compounds inhibited not only the survival of human caner cells, AGS gastric adenocarcinoma cell, HT-29 colon adenocarcinoma cell, HL-60 promyelocytic leukemia cell and MG-63 osteosarcoma cell, but also the synthesis of DNA within AGS cell. In particular, β-sitosterol showed the stronger in vitro anticancer activity than linoleic acid derivative. The present study suggests that anticancer effect of Chinese cabbage kimchi would be attributed to the active compounds, β-sitosterol and linoleic acid derivative.

Keywords: Kimchi, Anticancer effect, Cancer cell, β-sitosterol, Linoleic acid

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