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Journal of Cancer Prevention

Original Article

Cancer prevention research 2010; 15(2): 158-163

Published online June 30, 2010

© Korean Society of Cancer Prevention

Protective Effects of Black Rice against Free Radical-induced Oxidative Stress in Cellular System

Boh Kyung Kim1, Mi Jin Choi1, Sun Hwa Shin1, Hyun Young Kim2 and Eun Ju Cho1

Abstract

The protective effects of black rice from oxidative stress were investigated under cellular system using LLC-PK1 renal epithelial cells. The oxidative stress induced by 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) led to the loss of cell viability and increase of lipid peroxidation. However, the treatment of methanol extract from black rice significantly increased the cell viability and inhibited lipid peroxidation. In addition, the protective effect of black rice against nitric oxide (NO)-induced oxidative stress was also studied under cellular system. The oxidative stress were induced by the treatment with generators of peroxynitrite, 3-morpholinosydnonimine, and its precursors NO and superoxide anion produced by sodium nitroprusside and pyrogallol, respectively. The treatment of black rice extract attenuated NO-induced oxidative stress through the elevation in cell viability and decrease in lipid peroxidation. The present study suggests that black rice would have the protective effect from radical-induced oxidative stress in cellular system. (Cancer Prev Res 15, 158-163, 2010)

Keywords: Black rice, LLC-PK1 cell, Oxidative stress, Nitric oxide, Peroxyl radical

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