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Journal of Cancer Prevention


Journal of Korean Association of Cancer prevention 2004; 9(4): 237-243

Published online December 30, 2004

© Korean Society of Cancer Prevention

Role of Relish, a Drosophila NF-κB Protein, in Response to UV Irradiation

Young-Shin Kim1, Dong-Jin Yang2, Hyuck-Jin Nam3, So-Young Park2, Byeong-Gee Kim2,4 and Mi-Ae Yoo1,2


NF-κB has emerged as a central component of the cellular signaling machinery that serves as an important regulatory role in inflammation, immunity, and oncogenesis. During UV exposure, a positive correlation between NF-κB/Rel activation and its translocation to the nucleus, and phosphorylation and degradation of I-κB protein have been known in mammal. While the mechanisms involved in NF-κB activation upon inflammatory response are well documented both in flies and mammals, little is known that Drosophila NF-κB plays any functional roles in UV irradiation. In this study, using a null mutant of Relish, Drosophila NF-κB, we investigated a role of Drosophila NF-κB in response to UV irradiation. We found UV-induced NF-κB activation through gel mobility shift assay with the κB binding sequences of defensin promoter region. Relish null mutant larvae were more sensitive to UV-induced pigmentation, immunosuppression and apoptosis of hemocytes than wild-type. These results suggest that Drosophila NF-κB protein is involved in immune response and serves as an anti-apoptosis factor against UV irradiation.

Keywords: NF-κB, Relish, UV, Drosophila

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