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Journal of Cancer Prevention

Journal of Korean Association of Cancer prevention 1997; 2(1): 19-26

Published online March 31, 1997

© Korean Society of Cancer Prevention

Inhibition of Chemically Induced Carcinogenesis and Mutagenesis
by Some Natural Products and Synthetic Derivatives

Kwang-Kyun Park1, Ja-Hyun Lee1 , Seung-Hee Oh1 ,
Won-Young Lee2, Yeo-Won Sohn3 and Young-Joon Surh4

Abstract

Chemoprevention has been shown to be an extremly promising approach to the prevention of invasive cancer.
Through the identification of chemopreventive agents that block or reverse the process of carcinogenesis, new
strategies of early intervention can be developed for patients at high risk that potentially prevent the onset of
invasive and metastatic phases of cancer. This articles reviews the our result in chemoprevention research,
including natural products such as capsaicin, dially sulfide and gingerol, and structurally related compounds such
as chlorophyllin, dehydroparadol and 2-(allythio)pyrazine.

Keywords: Chemoprevention, Capsaicin, Diallyl sulfide, Gingerol, Paradol chlorophyllin,
Dehydroparadol, 2-(allythio)pyrazine, Vanilloids

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