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Journal of Cancer Prevention


Journal of Korean Association of Cancer prevention 2003; 8(2): 91-97

Published online June 30, 2003

© Korean Society of Cancer Prevention

Chemopreventive Effect of Xanthorrhizol from Curcuma xanthorrhiza

Jae-Hee Park, Mi-Jeong Kim, Kwang-Kyun Park, Heui-Og Kim, Jae-Kwan Hwang1 and Won-Yoon Chung


Xanthorrhizol is a sesquiterpenoid isolated from Curcuma xanthorrhiza that has been known to possess anti-inflammatory and anti-carcinogenic effects. In this work, we have found that xanthorrhizol reduced superoxide anion generation by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated HL-60 cells and exerted a dose-related inhibition of His reversion in Salmonella typhimurium TA102 induced by tert-butylhydroperoxide (t-BOOH) and hydrogen peroxide. Pretreatment of xanthorrhizol significantly decreased the incidence and the multiplicity of mouse skin tumors stimulated by TPA for 19 weeks after a single application of dimethylbenz[a]anthracene (DMBA), and mitigated the expression of epidermal ornithine decarboxylase in the skins. These results demonstrate that xanthorrhizol may be a potent cancer chemopreventive agent.

Keywords: Curcuma xanthorrhiza, Xanthorrhizol, Chemopreventive agent

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