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Journal of Cancer Prevention


Journal of Korean Association of Cancer prevention 2004; 9(2): 59-67

Published online June 30, 2004

© Korean Society of Cancer Prevention

Inhibition of Invasive Phenotype and Induction of Apoptosis in Human Breast Cancer Cells by Chemopreventive Agents

In Young Kim and Aree Moon


The most effective way to deal with cancer would be to prevent development of the cancer. Cancer chemoprevention is the treatment to block initiation or promotion- progression phases. Cancer metastasis represents the most important cause of cancer death and anti-tumor agents that may inhibit this process have been pursued. Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer, including the degrees of invasion and tumor recurrence. In this review article, we summarized several chemopreventive agents which inhibit invasive phenotype and/or induce apoptosis of H-ras-transformed MCF10A human breast epithelial cells. The molecular mechanism(s) underlying the cancer chemopreventive effects are also reviewed. A potential use of natural products including apicidin, Aster, curcumin and capsaicin for human breast cancer chemoprevention has been suggested.

Keywords: Apicidin, Aster, Curcumin, Capsaicin, H-ras, MCF10A cells, Invasion, Migration, MMP-2, Apoptosis

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