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Journal of Cancer Prevention

Original Article

Journal of cancer prevention 2013; 18(1): 80-87

Published online March 30, 2013

© Korean Society of Cancer Prevention

Anti-obesity Activities of Methyl Alcohol Extract of Enteromorpha linza in 3T3-L1 Preadipocytes

Eun-Ok Choi1,2, Hyang Suk Kim2,4, Min Ho Han3, Cheol Park5, Yung Hyun Choi2,3,6 and Hye-Jin Hwang2,3,4


The aim of this study was to evaluate a methyl alcohol extract of Enteromorpha linza (MEEL) for its anti-obesity effects. We demonstrated the inhibitory effects of MEEL on adipogenesis by investigating the lipolytic effects of MEEL in 3T3-L1 preadipocytes. Treatment with MEEL significantly suppressed terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner, as confirmed by a decrease in lipid droplet content observed by Oil Red O staining. The concentrations of cellular triglycerides were also reduced in 3T3-L1 cells after treatment of MEEL as compared with the controls. Treatment with 300 and 500 Ռg/ml of MEEL caused 67 and 19% reduction in lipid droplet content, respectively. In addition, MEEL significantly reduced the expression levels of key pro-adipogenic transcription factors including peroxisome proliferator-activated receptor Ճ (PPARՃ), cytidine-cytidine-adinosine-adenosine- thymidine (CCAAT)/enhancer binding proteins Ձ (C/EBPՁ) and C/EBPՂ as compared with controls. Taken together, these findings demonstrated that MEEL showed strong anti-obesity effects. (Cancer Prev Res 18, 80-87, 2013)

Keywords: Enteromorpha linza, 3T3-L1, Obesity, PPARՃ,, C/EBP

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