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Journal of Cancer Prevention

Journal of Korean Association of Cancer prevention 1998; 3(2): 128-135

Published online June 30, 1998

© Korean Society of Cancer Prevention

Antimutagenic and Anticarcinogenic Effect of Sorghum

Young-Mi Kweon and Kun-Young Park

Abstract

Antimutagenic effects of some cereals, legumes and oil seeds were studied using
Ames test on Salmonella typhimurium TA100. The methanol extracts of brown rice,
sorghum, black seasame, white seasame, and perilla seeds effectively inhibited the
mutagenicity induced by aflatoxin B1 (AFB1). To separate and identify the antimutagenic
and anticarcinogenic compounds from sorghum, the methanol extract
was fractionated by using various solvents such as dichloromethane, ethylacetate
and butanol. Among the solvent fractions from the methanol extract of sorghum,
the dichloromethane fraction significantly reduced the mutagenicity induced by
AFB1 in Salmonella typhimurium TA100. Using eukaryotic cells of C3H/10T1/2 cells,
the anticarcinogenic effect of the methanol extract and the dichloromethane
fraction of sorghum was evaluated. It revealed that they inhibited the cytotoxicity
of the MCA and reduced transformed foci induced by MCA.

Keywords: Sorghum, Antimutagenic, Anticarcinogenic, C3H/10T1/2 cells

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