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Journal of Cancer Prevention

Original

Journal of Korean Association of Cancer prevention 2002; 7(1): 19-26

Published online March 30, 2002

© Korean Society of Cancer Prevention

Regulation of Angiogenic Activity of Insulin-like Growth Factor II (IGF-II) in Chick Chorioallantoic Membrane

Myung-Ho Bae, Soo-Kyung Bae, Ok-Hee Lee, Yoo-Wook Kwon, Moon-Bum Kim1, Chang-Keun Oh1, Ho-Sun Jang1, Kyung-Sool Kwon1 and Kyu-Won Kim2

Abstract

Insulin-like growth factor II (IGF-II) is highly expressed during hepatocarcinogenesis and psoriasis. It has also angiogenic activity in quantitative chick chorioallantoic membrane (CAM) assay. However, the regulating factor of angiogenic activity of IGF-II is largely unknown. This study was undertaken to examine the control mechanism of angiogenic activity of IGF-II during the development of hepatocellular carcinoma and psoriasis. In this study, we examined angiogenic activity of IGF-II within HepG2 conditioned media by immunoprecipitaion and CAM assay. The EGF potentiated the angiogenic activity of IGF-II synergistically while heparin had no effect on the angiogenic activity of IGF-II. This effect of EGF may due to increased-activity of endothelial cell migration. However, EGF had no effect on the proliferating activity of endothelial cells. Finally, we demonstrated that IGF-IIR induced the expression of IGF-II. These results may examine the development mechanism of the hepatocellular carcinoma and psoriasis.

Keywords: Insulin like growth factor-II, Angiogenesis, Endothelial cell, Psoriasis

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