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Journal of Cancer Prevention

Original

Journal of Korean Association of Cancer prevention 2002; 7(1): 1-5

Published online March 30, 2002

© Korean Society of Cancer Prevention

Effects of Green Tea-Drinking on CYP1As in Different Tissues

Mihi Yang1,2, In-Seon Lee3, Masahiro Yoshikawa4, Keiichi Arashidani4 and Toshihiro Kawamoto5

Abstract

To study chemopreventive mechanism of green tea (GT), we studied the effects of GT-drinking on hepatic, pulmonary, and renal CYP1As against 3-methylcholanthrene (MC), which is a CYP1A-inducing carcinogen. Pre- and concurrent 2% GT drinking (11 days) was conducted in arylhyrocarbon receptor (AR) responsive C57 BL/6 mice. As results, GT drinking reduced MC-induced pulmonary ethoxyresorufin-O-demethylase (EROD)-activity, which is a probe for total CYP1As-activity including CYP1A1 and 1A2. In contrast, GT drinking enhanced MC-induced hepatic EROD-activity. EROD activity in kidney was lower than those in lung or liver and GT drinking did not affect MC-induced renal EROD activity. These results suggest that the different effects of GT on CYP1As are diverse in different tissues. Arylhydrocarbon hydroxylase (AHH) activity, which is known to reflect CYP1A1 activity, was not different according to GT drinking in lung, liver, or kidney. Therefore, CYP1A2 or other microsomal enzymes rather than CYP1A1 might be affected by GT in lung, liver and kidney. However, the changes of EROD activity by GT were not confirmed with CYP1A antibody. Our results suggest that susceptibility to chemopreventive GT against CYP1A-biotransformed carcinogens might be different in different tissues.

Keywords: Green tea, CYP1A, Chemoprevention

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