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Journal of Cancer Prevention

Original Article

Cancer prevention research 2009; 14(1): 16-19

Published online March 30, 2009

© Korean Society of Cancer Prevention

Chemopreventive Potentials of Korean Pears Against Occupational PAHs- Exposure: A Study Among Taxi Drivers in Seoul

Ho-Sun Lee and Mihi Yang

Abstract

Polycyclic aromatic hydrocarbons (PAHs) originate from incomplete combustion of carbohydrate compounds. Particularly, occupational exposure to high PAHs has been suspected to induce cancer. In addition, consumption of the Korean pears showed inverse association with level of urinary 1-hydroxypyrene (1-OHP), which is an exposure biomarker and metabolite of PAHs. Therefore, we investigated the effects of the Korean pears on level of urinary 1-OHP among male taxi drivers at Seoul, in a pilot study (for 3 days; N=6 of male smokers; age, 51.67±11.55 yrs). According to results, we found that the Korean pears stimulated excretion of urinary 1-OHP during 24 hrs compared to that without the pears. There were significant differences in 1-OHP levels due to 'the pear intake and time course' (p<0.001). In conclusion, our results suggest that the Korean pears may have chemopreventive effects on PAHs-induced cancer, particularly PAHs-high exposed people, via rapid excretion of bioactive intermediates. (Cancer Prev Res 14, 16-19, 2009)

Keywords: Korean pears, Taxi drivers, PAHs, 1-OHP, Chemopreventive effects

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