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Journal of Cancer Prevention

Original Article

Cancer prevention research 2011; 16(2): 141-146

Published online June 30, 2011

© Korean Society of Cancer Prevention

Montiporyne A Induces Apoptosis n SK-MEL-2 Human Melanoma Cells

Nam Deuk Kim, Kyoung-Mi Lee, Hye Joung Choi, Mohammad Akbar Hossain, Dong Hwan Kim, Jung Yoon Jang, Jee H. Jung and Jeong-Hyun Yoon


In this study, we investigated the effects of montiporyne A which was isolated from the stony coral Montipora species, on the proliferation of SK-MEL-2 human skin melanoma cells (mutant p53). Twenty-four hour treatment of montiporyne A inhibited the growth of melanoma cells and induced apoptotic cell death. This montiporyne A-induced apoptosis in the SK-MEL-2 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly(ADP-ribose) polymerase. Montiporyne A treatment also caused a marked increase in the level of p21WAF1/CIP1 protein in a p53-independent manner. Based on our data, montiporyne A can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to be confirm. (Cancer Prev Res 16, 141-146, 2011)

Keywords: Montiporyne A, Human skin cancer cells, Apoptosis

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