Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649

Subgroup analysis of discrepancy cases

Variable Helicobacter pylori seropositive by GENEDIA® H. pylori seronegative by GENEDIA® P-value


H. pylori seropositive by GastroPanel®
(n = 584)
H. pylori seronegative by GastroPanel®
(n = 67)
H. pylori seropositive by GastroPanel®
(n = 75)
H. pylori seronegative by GastroPanel®
(n = 350)
Age (yr) 58.15 ± 12.43 59.01 ± 11.97 62.09 ± 12.63 56.72 ± 14.70 0.012
Sex < 0.001
Male 389 (66.6) 39 (58.2) 53 (70.7) 171 (48.7)
Female 195 (33.4) 28 (41.8) 22 (29.3) 179 (51.3)
Atrophic gastritis < 0.001
Present 314 (65.4) 25 (52.1) 30 (51.7) 85 (31.5)
Absent 166 (34.6) 23 (47.9) 28 (48.3) 185 (68.5)
Intestinal metaplasia < 0.001
Present 337 (63.8) 26 (48.1) 32 (53.3) 114 (39.2)
Absent 191 (36.2) 28 (51.9) 28 (46.7) 177 (60.8)
Gastric adenoma 0.010
Present 107 (18.3) 12 (17.9) 11 (14.7) 36 (10.3)
Absent 477 (81.7) 55 (82.1) 64 (85.3) 315 (89.7)
Gastric cancer 0.002
Present 222 (38.0) 17 (25.4) 26 (34.7) 94 (26.8)
Absent 362 (62.0) 50 (74.6) 49 (65.3) 257 (73.2)
Previous history of H. pylori eradication < 0.001
Present 68 (11.9) 17 (27.0) 19 (27.1) 50 (14.9)
Absent 504 (88.1) 46 (73.0) 51 (72.9) 285 (85.1)
HpIgG titer on
GENEDIA® (OD)
1.88 ± 0.84 0.80 ± 0.52 0.19 ± 0.11 0.09 ± 0.09 < 0.001
HpIgG titer on
GastroPanel® (EIU)
272.60 ± 458.09 16.41 ± 0.82 27.42 ± 20.17 15.65 ± 0.73 < 0.001

Values are presented as number (%) or mean ± SD. Values are measured using GENEDIA® (GENEDIA H. pylori ELISA, Green Cross Co.) and GastroPanel® (GastroPanel ELISA, Biohit Oyj) kits. HpIgG, anti-H. pylori immunoglobulin G antibodies; OD, optical density; EIU, enzyme-immunosorbent units.

J Cancer Prev 2024;29:148~156 https://doi.org/10.15430/JCP.24.024
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