eISSN 2288-3657
pISSN 2288-3649
pISSN 2288-3649
Chemopreventive and anticarcinogenic effects of CuB and underlying mechanisms of action
| Type of cancer explored with phytochemical CuB | Mechanism of action | Results | References |
|---|---|---|---|
| Breast cancer | Inhibits JAK-STAT3, VEGF/FAK/MMP-9 MAPK, HER2 integrin signaling pathways. Suppresses HER2-integrin signaling which downregulates α6 and β4 integrins. |
Exceptionally displays anti-angiogenic effects in metastatic cancer cells. Limits the growth of breast tumors. Integrins α6 and β4 that are overexpressed in breast cancer cells are downregulated as HER2-integrin signaling is suppressed. Suppresses the growth of breast cancer cells when combined with gemcitabine or docetaxel. Inhibits VEGF/FAK/MMP-9 signaling in highly metastatic breast cancer cells and has anti-angiogenic properties. |
[7] |
| Colon cancer | Decreases phosphorylation of JAK2 and STAT3. Reduces M2 macrophage polarization. |
Reduces the metastasis of colorectal cancer. | [7,20] |
CuB, cucurbitacin B; JAK, Janus kinase; VEGF, vascular endothelial growth factor; FAK, focal adhesion kinase; MMP, matrix metalloproteinase; MAPK, mitogen-activated protein kinase.
J Cancer Prev 2024;29:58~68 https://doi.org/10.15430/JCP.24.020
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