Fig. 6. Metascape pathway analysis of differentially methylated regions (DMRs) at contrasting hyper/hypomethylated intragenic regions. Hypomethylation at these DMRs was associated mainly with postsynaptic organization (GO:0099173) and morphogenesis of plasma membrane-bounded cell projections (GO:0120039). Hypermethylation was associated with extracellular matrix organization (R-MMU-1474244) and regulation of membrane potential (GO:0042391). LGI-ADAM, leucine-rich, glioma-inactivated 1-a disintegrin and metalloprotease domain.