Fig. 3. Metascape pathway analysis of differentially methylated regions (DMRs) at contrasting hyper/hypomethylated transcription start site (TSS) and intragenic regions.
Hypomethylation at these DMRs was associated mainly with synapse organization (GO:0050808) and morphogenesis of plasma membrane-bounded cell projections (GO:0120039). Hypermethylation was associated with cancer pathways (mmu05200) and collagen formation (R-MMU-1474290). HS-GAG, heparan sulfate-glycosaminoglycan; MAPK, mitogen-activated protein kinase; GPCR, G protein coupled receptors.

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