Baseline characteristics of the 43 patients with metastatic CRC
Characteristic | Total patients (n = 43) |
---|---|
Age (yr) | |
Median (range) | 63 (21-79) |
≥ 63 | 24 (55.8) |
< 63 | 19 (44.2) |
ECOG PS score | |
0-1 | 23 (53.5) |
2 | 20 (46.5) |
Sex | |
Male | 27 (62.8) |
Female | 16 (37.2) |
Pathological stage | |
IIIb | 4 (9.3) |
IV | 39 (90.3) |
Primary tumor site | |
Right | 18 (41.9) |
Left or rectum | 25 (58.1) |
Previous systemic treatment | |
Second line | 11 (25.6) |
Third line and above | 32 (74,4) |
Surgical treatment history | |
Yes | 27 (62.8) |
No | 16 (37.2) |
MMR status | |
dMMR | 4 (9.3) |
pMMR | 24 (55.8) |
Unknown | 15 (34.9) |
Number of metastases sites | |
≤ 3 | 24 (55.8) |
> 3 | 19 (44.2) |
Liver metastases | |
Yes | 31 (72.1) |
No | 12 (27.9) |
Initial dosage of apatinib (mg) | |
250 | 26 (60.5) |
500 | 17 (39.5) |
PD-1 blockades | |
Camrelizumab | 23 (53.5) |
Sintilimab | 14 (32.6) |
Pembrolizumab | 6 (13.9) |
Values are presented as number (%) or otherwise indicated. CRC, colorectal cancer; ECOG, Eastern Cooperative Oncology Group; PS, performance status; MMR, mismatch repair; dMMR, mismatch repair-deficient; pMMR, proficient mismatch repair; PD-1, programmed cell death protein 1.