Fig. 3. Butyric acid and bile acid (BA) concentrations in fecal samples from repeated water avoidance stress (WAS) experiments with two different Roseburia faecis strains as probiotic candidates.
(A) The butyric acid concentration in feces after 10 days of WAS sessions. Unexpectedly, there was no statistical significance in both (A) BBH024 and (B) R22-12-24 strains and no correlation with previous cultured media results was noted. (C, D) The ratio of cholic acid (CA, primary BA) to deoxycholic acids (DCAs, secondary BA) in feces after 10 days of WAS sessions. In the case of R22-12-24, females showed significantly decreased levels of CA/DCA ratio (D, P = 0.025). (E, F) The ratio of chenodeoxycholic acid (CDCA, primary BA) to lithocholic acids (LCA, secondary BA) in feces after 10 days of WAS sessions. In the case of BBH024, females showed significantly decreased levels of CDCA/LCA ratio (E, P = 0.027). CON, control.

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