Fig. 1. The fecal pellet output (FPO) and mast cell count from each repeated water avoidance stress (WAS) experiment with two different Roseburia faecis strains as probiotics candidates.
FPO data represent the 10-day sessions with weight calibration for male and female rats in the BBH024 experiments. The difference between male and female body weight was normalized by multiplying female FPO with the ratio of male body weight to female body weight. The cumulative FPO differed significantly between WAS-exposed groups and no-stress group in the later stages of BBH024 experiments (A) male and (B) female, as well as the R22-12-24 experiments (C) male and (D) female. The mean FPO of (E) BBH024 experiment and (F) R22-12-24 experiment indicated a significant reduction in FPO in WAS with probiotics group with statistical significance. The mucosal mast cells were counted from toluidine blue stained colonic tissue slides about each gavaged R. faecis strain, (G) BBH024, and (H) R22-12-24. The mast cell count in the colonic mucosa was divided into the area of the colonic mucosa. CON, control.

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