Journal of Cancer Prevention

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Fig. 3.

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Fig. 3. Baicalein prevents melanogenesis and pigmentation via the p38 MAPK pathway. The 1 µM α-MSH was treated to the cells for 12 hours, then baicalein or SB203580 was added. (A-C) The expression levels of the p38, phospho-p38, tyrosinase, and TRP-2 proteins were examined by Western blot analysis, with actin used as the loading control. (D) Melanin contents and (E) tyrosinase activity were measured with and without SB203580 and/or baicalein. *P < 0.05 and #P < 0.05 compared to the control and α-MSH-treated cells. MAPK, mitogen-activated protein kinase; α-MSH, α-melanocyte-stimulating hormone; TRP, tyrosine-related protein.
J Cancer Prev 2023;28:40~46
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