Journal of Cancer Prevention

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Fig. 4.

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Fig. 4. BRBs-induced differential changes in methylation in each MDS/MPN patient. (A) The PCA plot, with each line connecting global pre- and post-methylation data from each patient; the longer the line, the larger the differences between global pre- and post-methylation levels. In particular, lines connecting pre- and post-samples in BRB18, BRB19, and BRB20 were much longer than those in the other 12 patients. (B) Methylation changes 500 bp up- and downstream of the TSS (FDR < 0.01, P < 0.05) were identified. In particular, BRB18, BRB19, and BRB20 had more significant changes in methylation; this corresponded with the visualization demonstrated in (A). BRB, black raspberry; MDS/MPN, myelodysplastic syndromes/myeloproliferative neoplasms; PCA, principal component analysis; FDR, false discovery rates; TSS, transcription start site.
J Cancer Prev 2022;27:129~138 https://doi.org/10.15430/JCP.2022.27.2.129
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