Fig. 2. Differentially methylation region (DMR) de novo before and after BRB intervention.
Metilene was used to identify de novo differentially methylated regions before and after BRB intervention. Among 189 identified DMRs reaching FDR < 0.05, 72, 79, and 38 were located at TSS, Intragenic and Intergenic regions, respectively (A). The methylation rate of DMRs after BRB intervention was higher than before BRB intervention (B-D), especially in the region of Intergenic (B). DMR, differentially methylated region; FDR, false discovery rates; TSS, transcription start site; BRB, black raspberry.