Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649

A list of actin cytoskeleton-associated genes significantly (P ≤ 0.05) upregulated by DATS treatment in the SK-BR-3 cell line

Gene name MCF-10A SK-BR-3 Gene description
Fold change P-value Fold change P-value
ACKR2 1.24 0.4100 1.48 0.0135 Atypical chemokine receptor 2
ACTB 1.26 0.2035 1.25 0.0306 Actin beta
ACTBL2 2.49 0.1142 3.11 0.0062 Actin, beta like 2
ACTR10 1.16 0.1731 1.26 0.0002 Actin related protein 10 homolog
AFAP1L1 1.13 0.1995 2.98 0.0033 Actin filament associated protein 1 like 1
ANLN –1.45 0.0188 1.50 0.0040 Anillin actin binding protein
ARHGAP21 1.06 0.4300 1.50 0.0313 Rho GTPase activating protein 21
ARPC2 1.20 0.2129 1.43 0.0047 Actin related protein 2/3 complex subunit 2
ASAP1 1.08 0.3273 1.44 0.0261 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BCAR1 1.37 0.0851 1.33 0.0364 BCAR1, Cas family scaffold protein
BIN1 –1.24 0.0375 1.57 0.0074 Bridging integrator 1
BIN2 Not detected 4.54 0.0042 Bridging integrator 2
CAP2 1.05 0.3896 1.30 0.0029 Cyclase associated actin cytoskeleton regulatory protein 2
CAPZA2 1.15 0.1962 1.26 0.0010 Capping actin protein of muscle Z-line subunit alpha 2
CASK 1.06 0.1780 1.29 0.0281 Calcium/calmodulin dependent serine protein kinase
CD2AP 1.05 0.4486 1.34 0.0332 CD2 associated protein
CDC42BPA 1.12 0.0983 1.32 0.0136 CDC42 binding protein kinase alpha
CFL2 1.12 0.3922 1.72 0.0019 Cofilin 2
CORO1C 1.10 0.2186 1.44 0.0099 Coronin 1C
COTL1 1.22 0.0791 1.65 0.0102 Coactosin like F-actin binding protein 1
CRK 1.11 0.0882 1.24 0.0046 CRK proto-oncogene, adaptor protein
CRYAB 1.74 0.2224 3.39 0.0476 Crystallin alpha B
CTNNA1 1.17 0.0796 1.26 0.0251 Catenin alpha 1
CTTN 1.17 0.1458 1.22 0.0478 Cortactin
DBN1 1.30 0.0556 1.68 0.0127 Drebrin 1
DCTN6 1.17 0.2016 1.37 0.0053 Dynactin subunit 6
EEF1A1 1.02 0.4486 1.18 0.0101 Eukaryotic translation elongation factor 1 alpha 1
EPB41L2 –1.03 0.7086 10.17 0.0362 Erythrocyte membrane protein band 4.1 like 2
FER –1.08 0.0055 1.55 0.0080 FER tyrosine kinase
FLNA 1.04 0.6271 1.39 0.0427 Filamin A
GAS2L3 –1.30 0.2667 1.84 0.0060 Growth arrest specific 2 like 3
GAS7 1.01 0.9813 4.36 0.0023 Growth arrest specific 7
GBP2 1.63 0.0703 1.79 0.0502 Guanylate binding protein 2
GMFB 1.00 0.9908 1.35 0.0180 Glia maturation factor beta
ITSN1 1.08 0.2819 1.71 0.0070 Intersectin 1
KLHL2 –1.03 0.6052 1.88 0.0196 Kelch like family member 2
LIMA1 1.38 0.0708 1.67 0.0167 LIM domain and actin binding 1
LIMCH1 1.27 0.0641 1.30 0.0277 LIM and calponin homology domains 1
MICAL1 1.43 0.0692 1.60 0.0105 Microtubule associated monooxygenase, calponin and LIM domain containing 1
MYL12A 1.38 0.2107 1.58 0.0002 Myosin light chain 12A
MYL12B 1.32 0.2112 1.50 0.0052 Myosin light chain 12B
MYO10 1.13 0.1758 1.63 0.0263 Myosin X
MYO7B 1.84 0.0956 2.33 0.0106 Myosin VIIB
MYOM1 –1.17 0.7071 4.96 0.0243 Myomesin 1
NCKAP1 –1.02 0.4588 1.46 0.0005 NCK associated protein 1
NDC1 –1.44 0.0180 1.27 0.0013 NDC1 transmembrane nucleoporin
PAWR –1.02 0.6527 1.33 0.0533 Pro-apoptotic WT1 regulator
PDCD6IP 1.12 0.1263 1.32 0.0080 Programmed cell death 6 interacting protein
PEAK1 –1.03 0.8576 1.52 0.0068 Pseudopodium enriched atypical kinase 1
PLS1 1.05 0.4272 1.62 0.0407 Plastin 1
PLS3 1.13 0.1160 1.56 0.0057 Plastin 3
RDX –1.12 0.0244 1.38 0.0146 Radixin
SEPT7 1.04 0.5335 1.33 0.0197 Septin 7
SH2B2 1.37 0.1005 1.54 0.0090 SH2B adaptor protein 2
SPECC1 1.04 0.5224 1.32 0.0092 Sperm antigen with calponin homology and coiled-coil domains 1
SPTA1 Not detected 4.03 0.0117 Spectrin alpha, erythrocytic 1
TLN2 1.00 0.9898 1.95 0.0002 Talin 2
TMOD1 1.16 0.7239 4.16 0.0002 Tropomodulin 1
TPM1 1.28 0.4564 1.69 0.0016 Tropomyosin 1
TPM3 1.14 0.3401 1.23 0.0051 Tropomyosin 3
TPM4 1.29 0.1956 1.37 0.0163 Tropomyosin 4
TWF1 1.04 0.5886 1.27 0.0408 Twinfilin actin binding protein 1
UTRN 1.03 0.7276 1.35 0.0499 Utrophin
WDR1 1.29 0.2219 1.37 0.0064 WD repeat domain 1
YES1 –1.01 0.7511 1.41 0.0069 YES proto-oncogene 1, Src family tyrosine kinase
J Cancer Prev 2022;27:101~111 https://doi.org/10.15430/JCP.2022.27.2.101
© J Cancer Prev
Copyright © Korean Society of Cancer Prevention. / Powered by INFOrang Co., Ltd