Fig. 4. Mannose disturbed the glucose metabolism in colon cancer cells without affecting their growth. (A) Effect of mannose (Man) on cell viability (HCT116, HT29, SW620, and CT26). (B, C) Effect of mannose on the anchorage-independent growth of colon cancer cells (×100). (D) Effect of mannose on the consumption of glucose in HCT116 cells. (E) Effect of mannose on production of lactate in HCT116 cells. (F) The protein levels of GLUT1 and HK II in HCT116 cells. The cells were treated with 1, 3, and 10 mmol/L mannose for 24 hours. Data represent the mean ± standard deviation. HK II, hexokinase II; GLUT1, glucose transporters 1; ns, not significant. *P < 0.05 and ***P < 0.001 compared with the control group.

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