Fig. 1. Mannose attenuated colitis-associated tumorigenesis. (A) Experimental protocol for CRC animal model. Normal mice (Control); mice were treated with 2,000 mg/kg mannose (Man); mice treated with AOM plus DSS (AOM/DSS); mice treated with AOM plus DSS and 1,000 mg/kg mannose (AOM/DSS + L Man; mice treated with AOM plus DSS and 2,000 mg/kg mannose (AOM/DSS + H Man). (B) Representative photos of the colons. (C) Effect of mannose on the ratio of colon weight to colon length. (D) Effect of mannose on the number of tumors. (E) Effect of mannose on the percentage of different neoplasms sizes. (F) Representative H&E staining of the colon from each group of mice. Data represent the mean ± standard deviation (n = 10). CRC, colorectal cancer; AOM, azoxymethane; DSS, dextran sodium sulfate. *P < 0.05 and ***P < 0.001 compared with the AOM/DSS group.

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