Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649
Fig. 1.

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Fig. 1. Intestinal tumor phenotypes linked to specific combinations of driver mutations, Apc, Tgfbr2, Smad4, Trp53, and Fbxw7. Typical morphology of the intestinal tumor tissue is drawn for each genotype. Green lines, basal membranes; thin brown lines, smooth muscle layers; thick brown lines, fibrotic niche; red circles, capillary vessels. Note that intravasations were found in triple mutant tumors. PGE2, prostaglandin E2; EMT, epithelial-mesenchymal transition; MSI, microsatellite instability; GOF, gain-of-function.
J Cancer Prev 2022;27:1~6
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