Fig. 1. Intestinal tumor phenotypes linked to specific combinations of driver mutations, Apc, Tgfbr2, Smad4, Trp53, and Fbxw7. Typical morphology of the intestinal tumor tissue is drawn for each genotype. Green lines, basal membranes; thin brown lines, smooth muscle layers; thick brown lines, fibrotic niche; red circles, capillary vessels. Note that intravasations were found in triple mutant tumors. PGE₂, prostaglandin E₂; EMT, epithelial-mesenchymal transition; MSI, microsatellite instability; GOF, gain-of-function.

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