Journal of Cancer Prevention

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pISSN 2288-3649
Fig. 5.

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Fig. 5. Anti-angiogenic effects of bitter melon variants (BMJ and BME). (A) Representative pictures demonstrate the in vitro tube formation on Matrigel at 9 hours; the formation of human umbilical vein epithelial cells (HUVECs) capillary-like structures in was inhibited by treatment with BMJ or BME (magnification: ×100). (B) Quantitative analysis of the capillary-like tube formation assay depicting total tube length, total mesh area, and total segment length (upper panel). Also shown are bar graphs for the number of nodes, number of junctions, and number of segments (lower panel) (magnification: ×400). (C) Representative pictures and qualitative analysis for immunohistochemical analysis of an angiogenic marker (CD-31) in PanC tumor xenografts. Values are means ± SEM. BMJ, bitter melon juice; BME, bitter melon extract; CD-31, cluster of differentiation 31. *P < 0.05, **P < 0.01, ***P < 0.001.
J Cancer Prev 2021;26:266~276
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