Journal of Cancer Prevention

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Fig. 2.

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Fig. 2. In vivo efficacy of bitter melon variants (BMJ and BME feeding) against human pancreatic cancer PANC-1 tumor xenografts. (A) Growth curve depicting tumor volumes plotted as a function of time. (B) Bar graph representing the tumor volumes at the end of the experiment shows a significant decrease in tumor size in the treatment groups compared to control. (C) Representative images of H&E (tumor tissue sections) and IHC for Ki-67 and cleaved caspase-3. Quantitative analysis of IHC depicting the decrease in proliferation (D) and an increase in apoptosis (E) in BMJ and BME treated groups. For all the above experiments, mice were treated with 200 mg/kg BMJ or BME in 100 µL water (oral gavage). Control mice were oral gavaged with 100 µL of water only as described in the material and methods section. All pictures were taken at 400× magnification. Values are means ± SEM. BMJ, bitter melon juice; BME, bitter melon extract; IHC, Immunohistochemistry. *P < 0.05, **P < 0.01, ***P < 0.001.
J Cancer Prev 2021;26:266~276 https://doi.org/10.15430/JCP.2021.26.4.266
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