Fig. 4. Asbestos-induced ferroptosis in macrophages emits ferroptosis-dependent extracellular vesicles (FedEVs; filled stars), which is received by surface mesothelial cells resulting in oxidative DNA damage. Note that there are direct and indirect damage by asbestos fibers to surface mesothelial cells in the somatic cavities. Macrophages with pyknotic nucleus are undergoing ferroptosis while the other macrophages are alive. Mesothelial cells with yellow/red filled nucleus present mild/severe oxidative damage in the genomic DNA, predisposing to carcinogenesis.

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